Relation of structural features to pyrrolic metabolites in livers of rats given pyrrolizidine alkaloids and derivatives.

@article{Mattocks1981RelationOS,
  title={Relation of structural features to pyrrolic metabolites in livers of rats given pyrrolizidine alkaloids and derivatives.},
  author={A. R. Mattocks},
  journal={Chemico-biological interactions},
  year={1981},
  volume={35 3},
  pages={301-10}
}
Levels of pyrrolic metabolites have been measured in the livers of rats given some pyrrolizidine alkaloids and semisynthetic derivatives. Structural and chemical features favouring the formation of such metabolites have been defined. The most important of these were: steric hindrance or chemical properties giving resistance to ester hydrolysis; lipophilic character, allowing access to hepatic microsomal enzymes; a conformation favoring microsomal oxidation of the pyrroline ring in preference to… CONTINUE READING