Relation of renin-angiotensin system activity to left ventricular hypertrophy and function in experimental and human hypertension.

@article{Devereux1987RelationOR,
  title={Relation of renin-angiotensin system activity to left ventricular hypertrophy and function in experimental and human hypertension.},
  author={Richard Blyton Devereux and Thomas G. Pickering and Robert J. Cody and John H. Laragh},
  journal={Journal of clinical hypertension},
  year={1987},
  volume={3 1},
  pages={87-103}
}
This article examines available data concerning the hypothesis that the renin-angiotensin system directly stimulates cardiac hypertrophy and dysfunction in hypertension. Several experiments support a direct effect of angiotensin on myocardial protein synthesis and suggest that this may be independent of adrenergic influences. However, the role played by the renin system in the pathogenesis of hypertensive cardiac hypertrophy may be small, for left ventricular (LV) muscle mass is not… CONTINUE READING

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