Relation of positive inotropic and chronotropic effects of pimobendan, UD-CG 212 Cl, milrinone and other phosphodiesterase inhibitors to phosphodiesterase III inhibition in guinea-pig heart

@article{Brunkhorst1989RelationOP,
  title={Relation of positive inotropic and chronotropic effects of pimobendan, UD-CG 212 Cl, milrinone and other phosphodiesterase inhibitors to phosphodiesterase III inhibition in guinea-pig heart},
  author={Detlef Brunkhorst and Heiko von der Leyen and Wilfried Meyer and R{\"u}diger Nigbur and Carlos Schmidt-Schumacher and Hasso Scholz},
  journal={Naunyn-Schmiedeberg's Archives of Pharmacology},
  year={1989},
  volume={339},
  pages={575-583}
}
(1) This study was performed to elucidate the relation between positive inotropy and phosphodiesterase inhibition in the heart. Therefore, the influence on the activity of guinea-pig cardiac phosphodiesterase (PDE) I–III separated by DEAE-cellulose anion exchange chromatography was investigated for the new cardiotonic agents pimobendan, its metabolite UD-CG 212 Cl and milrinone. These effects were compared with those of various other PDE inhibitiors such as IBMX, zaprinast, rolipram and AR-L 57… CONTINUE READING
BETA

Citations

Publications citing this paper.
SHOWING 1-10 OF 31 CITATIONS

References

Publications referenced by this paper.
SHOWING 1-10 OF 35 REFERENCES

Mechanism of action and cardiotonic activity

  • H Scholz
  • 1988

Mechanism of action and cardiotonic activity of a new phosphodiesterase inhibitor , the benzimidazole derivative adibendan ( BM 14 . 478 ) , in guinea - pig hearts

  • Bethke Th, D Brunkhorst, H v.derLeyen, W Meyer, R Nigbur, H Scholz
  • Naunyn - Schmiedeberg ' s Arch Pharmacol
  • 1988

Sensitization of dog

  • N Sperelakis, RJ Solaro
  • 1988

Calcium sensitizing and PDE - inhibiting action of the novel cardiotonic BM 14 . 478 - - a comparison with other new compounds

  • P Freund, W Bartsch, M Grfinewald, U Meboldt, L Kling
  • Naunyn - Schmiedeberg ' s Arch Pharmacol
  • 1987

Effects of some cardiotonic agents on contractility of skinned fibers from mammalian heart

  • van Meel JCA
  • 1987

The identification

  • ML Reeves, BK Leigh, PJ England
  • schung
  • 1987
1 Excerpt

Similar Papers

Loading similar papers…