Relation of mitochondrial and cytosolic free calcium to cardiac myocyte recovery after exposure to anoxia.

@article{Miyata1992RelationOM,
  title={Relation of mitochondrial and cytosolic free calcium to cardiac myocyte recovery after exposure to anoxia.},
  author={Hirsohi Miyata and Edward G. Lakatta and Michael D. Stern and H. S. Silverman},
  journal={Circulation research},
  year={1992},
  volume={71 3},
  pages={605-13}
}
Mitochondrial calcium overload has been suggested as a marker for irreversible injury in the ischemic heart. A new technique is used to measure dynamic changes in mitochondrial free calcium concentration ([Ca2+]m) in electrically stimulated (0.2 Hz) adult rat cardiac myocytes during exposure to anoxia and reoxygenation. Cells were incubated with indo-1 AM, which distributes in both the cytosol and mitochondria. After Mn2+ quenching of the cytosolic signal, cells were exposed to anoxia, and the… CONTINUE READING

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