Relation of hypoxia-inducible factor-2 alpha (HIF-2 alpha) expression in tumor-infiltrative macrophages to tumor angiogenesis and the oxidative thymidine phosphorylase pathway in Human breast cancer.

@article{Leek2002RelationOH,
  title={Relation of hypoxia-inducible factor-2 alpha (HIF-2 alpha) expression in tumor-infiltrative macrophages to tumor angiogenesis and the oxidative thymidine phosphorylase pathway in Human breast cancer.},
  author={R. Leek and Kate L. Talks and Francesco Pezzella and Helen Turley and Leticia Campo and Nicholas Samuel Brown and Roy Bicknell and Marian S. Taylor and Kevin C. Gatter and Adrian L. Harris},
  journal={Cancer research},
  year={2002},
  volume={62 5},
  pages={1326-9}
}
Tumor-associated macrophages (TAMs) produce angiogenic factors and in breast cancer are associated with high vascular grade and poor survival. TAMs preferentially migrate to hypoxic areas within tumors and strongly express hypoxia-inducible factor (HIF)-2 alpha. This study examined whether HIF-2 alpha was involved in TAM angiogenic activation by correlating its expression with tumor microvessel density as a marker of angiogenesis, and other tumor variables, in a series of human primary invasive… CONTINUE READING

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