Relation of glomerular injury to preglomerular resistance in experimental hypertension.

@article{Olson1986RelationOG,
  title={Relation of glomerular injury to preglomerular resistance in experimental hypertension.},
  author={Jean L. Olson and Stephen K Wilson and R H Heptinstall},
  journal={Kidney international},
  year={1986},
  volume={29 4},
  pages={849-57}
}
A semiquantitative glomerular damage index (GDI) was determined for overall (O), superficial (S), and juxtamedullary (JM) glomeruli in four models of experimental hypertension in the rat to assess the severity and distribution of injury in light of present day knowledge of glomerular hemodynamics. After a four week period of similar hypertension, comparison of Group 1 (renal ablation) with Group 2 (aortic ligature) revealed OGDIs of 0.420 +/- 0.064 (SEM) vs. 0.062 +/- 0.019, P less than 0.0001… CONTINUE READING

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