Relation of dopamine receptor 2 binding to pain perception in female fibromyalgia patients with and without depression--A [¹¹C] raclopride PET-study.

@article{Ledermann2016RelationOD,
  title={Relation of dopamine receptor 2 binding to pain perception in female fibromyalgia patients with and without depression--A [¹¹C] raclopride PET-study.},
  author={Katharina Ledermann and Josef Jenewein and Haiko Sprott and Gregor Hasler and Ulrich Schnyder and Geoffrey Warnock and Anass Johayem and Spyros Sreejanth Kollias and Alfred Buck and Chantal Martin-Soelch},
  journal={European neuropsychopharmacology : the journal of the European College of Neuropsychopharmacology},
  year={2016},
  volume={26 2},
  pages={320-330}
}
Dopamine D2/D3 receptor availability at rest and its association with individual pain perception was investigated using the [(11)C] raclopride PET-method in 24 female Fibromyalgia (FMS) participants with (FMS+, N=11) and without (FMS-, N=13) comorbid depression and in 17 healthy women. Thermal pain thresholds (TPT) and pain responses were assessed outside the scanner. We compared the discriminative capacity, i.e. the individual׳s capacity to discriminate between lower and higher pain… CONTINUE READING
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