Relation of cognitive activity to risk of developing Alzheimer disease

  title={Relation of cognitive activity to risk of developing Alzheimer disease},
  author={R. Wilson and P. Scherr and J. Schneider and Y. Tang and D. Bennett},
  pages={1911 - 1920}
  • R. Wilson, P. Scherr, +2 authors D. Bennett
  • Published 2007
  • Psychology, Medicine
  • Neurology
  • Background: Frequent cognitive activity in old age has been associated with reduced risk of Alzheimer disease (AD), but the basis of the association is uncertain. Methods: More than 700 old people underwent annual clinical evaluations for up to 5 years. At baseline, they rated current and past frequency of cognitive activity with the current activity measure administered annually thereafter. Those who died underwent a uniform postmortem examination of the brain. Amyloid burden, density of… CONTINUE READING
    305 Citations

    Paper Mentions

    Interventional Clinical Trial
    This study is aimed to investigate the efficacy of an 12-week Chinese calligraphy training program for enhancing cognitive and emotional functions of older adults with mild cognitive… Expand
    ConditionsMild Cognitive Impairment
    Cognitive activity and the cognitive morbidity of Alzheimer disease
    • 102
    Early-Life Cognitive Activity Is Related to Reduced Neurodegeneration in Alzheimer Signature Regions in Late Life
    • 9
    • PDF
    Vulnerability to stress, anxiety, and development of dementia in old age.
    • 120
    Risk Factors for Alzheimer’s Disease
    • 1
    • PDF
    Harm Avoidance and Risk of Alzheimer's Disease
    • 19
    Life-span cognitive activity, neuropathologic burden, and cognitive aging
    • 148
    Is Alzheimer's Disease Risk Modifiable?
    • 12


    Mild cognitive impairment
    • 140
    Loneliness and risk of Alzheimer disease.
    • 781
    • PDF