Relation of central obesity and insulin resistance with high diabetes prevalence and cardiovascular risk in South Asians

  title={Relation of central obesity and insulin resistance with high diabetes prevalence and cardiovascular risk in South Asians},
  author={Paul M. McKeigue and Bijal M Shah and Michael Marmot},
  journal={The Lancet},

Metabolic consequences of obesity and body fat pattern: lessons from migrant studies.

In Afro-Caribbean migrants, the prevalence of diabetes is almost as high as in South Asians but the lipid disturbances characteristic of the insulin resistance syndrome do not occur to the same extent, which may account for the low rates of coronary heart disease in this group.

Insulin resistance, diabetes, and risk markers for ischaemic heart disease in Asian men and non-Asian in Bradford.

Data support the insulin resistance hypothesis and thus have important implications for strategies for the prevention of heart disease in Asian communities in the United Kingdom.

Insulin resistance, high prevalence of diabetes, and cardiovascular risk in immigrant Asians. Genetic or environmental effect?

A predisposition to insulin resistance and its metabolic abnormalities in this group of Asians seems to be genetically determined, environmental changes after migration having only a small additional effect.

Relationship of glucose intolerance and hyperinsulinaemia to body fat pattern in South Asians and Europeans

In both groups glucose intolerance was more strongly associated with waist-hip girth ratio than with skinfolds or body mass index, and the association between hyperinsulinaemia and obesity is less specific for centrally-distributed fat.

Association of Early‐Onset Coronary Heart Disease in South Asian Men With Glucose Intolerance and Hyperinsulinemia

These results are consistent with the hypothesis that insulin resistance underlies the high coronary risk in South Asian people and strengthen the evidence for a fundamental role of this metabolic pattern in the etiology of coronary heart disease.

Abdominal Fat Distribution and Insulin Levels Only Partially Explain Adverse Cardiovascular Risk Profile in Asian Indians

The data suggest that it is over-simplistic to ascribe the adverse cardiovascular risk factor profile commonly observed in Asian Indians to a tendency to abdominal obesity, and ethnic differences in cardiovascular risk factors in Mauritians were not explained.

Diabetes and cardiac disease in South Asians

There is little evidence for measures to reduce cardiovascular risk as South Asians have not been included as a subgroup in most large trials and future prospective studies, including studies on the prevention of diabetes and cardiovascular disease in this high-risk population are urgently required.

Impaired skeletal muscle fat oxidation as a mechanism for insulin resistance in South Asians

Reduced oxidative capacity and capacity for fatty acid utilisation at the whole body level are key features of the insulin resistant phenotype observed in South Asians, but that this is not the consequence of reduced skeletal muscle expression of oxidative and lipid metabolism genes.

Type 2 diabetes in East Asians: similarities and differences with populations in Europe and the United States

  • R. MaJ. Chan
  • Medicine
    Annals of the New York Academy of Sciences
  • 2013
East Asian patients with type 2 diabetes have a higher risk of developing renal complications than Europeans and, with regard to cardiovascular complications, a predisposition for developing strokes and cancer is emerging as the other main cause of mortality.



Diabetes, hyperinsulinaemia, and coronary risk factors in Bangladeshis in east London.

Insulin resistance, leading to diabetes, hyperinsulinaemia, and secondary lipoprotein disturbances, is a possible mechanism for the high rates of coronary heart disease in South Asians in Britain and overseas.

Diabetes incidence in Pima indians: contributions of obesity and parental diabetes.

In the Pimas, both obesity and diabetes have become more common during this century, perhaps as a result of rapid cultural and dietary changes in a population genetically susceptible to diabetes.

Relation of Body Fat Distribution to Metabolic Complications of Obesity

In women, the sites of fat predominance offer an important prognostic marker for glucose intolerance, hyperinsulinemia, and hypertriglyceridemia, may be related to the disparate morphology and metabolic behavior of fat cells associated with different body fat distributions.

Cardiovascular risk factors in Mexican Americans in Laredo, Texas. I. Prevalence of overweight and diabetes and distributions of serum lipids.

An epidemiologic survey of cardiovascular risk factors was carried out on a random sample of Mexican Americans living in two low income census tracts in Laredo, Texas and found the prevalence of overweight and fasting hyperglycemia to be intermediate between US national estimates and the rates recorded for Pima Indians.