Relation of addiction genes to hypothalamic gene changes subserving genesis and gratification of a classic instinct, sodium appetite.

@article{Liedtke2011RelationOA,
  title={Relation of addiction genes to hypothalamic gene changes subserving genesis and gratification of a classic instinct, sodium appetite.},
  author={Wolfgang B Liedtke and Michael Joseph McKinley and Lesley L. Walker and Hao Zhang and Andreas R. Pfenning and John L Drago and Sarah J. Hochendoner and Donald L. Hilton and Andrew J Lawrence and Derek A. Denton},
  journal={Proceedings of the National Academy of Sciences of the United States of America},
  year={2011},
  volume={108 30},
  pages={
          12509-14
        }
}
Sodium appetite is an instinct that involves avid specific intention. It is elicited by sodium deficiency, stress-evoked adrenocorticotropic hormone (ACTH), and reproduction. Genome-wide microarrays in sodium-deficient mice or after ACTH infusion showed up-regulation of hypothalamic genes, including dopamine- and cAMP-regulated neuronal phosphoprotein 32 kDa (DARPP-32), dopamine receptors-1 and -2, α-2C- adrenoceptor, and striatally enriched protein tyrosine phosphatase (STEP). Both DARPP-32… CONTINUE READING

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