Relation between triketone structure, generation of reactive oxygen species, and selective toxicity of the diabetogenic agent alloxan.

Abstract

The diabetogenic agent alloxan is a triketone that selectively destroys pancreatic beta cells. To investigate the importance of the triketone structure of alloxan for its cytotoxic potency, alloxan was compared with ninhydrin, also a triketone, and the amino derivative of alloxan uramil, which is not a triketone, because the 5-keto group of the alloxan is… (More)
DOI: 10.1089/ars.2007.1816

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