Relation between the action of dopamine and apomorphine and their O-methylated derivatives upon the CNS

  title={Relation between the action of dopamine and apomorphine and their O-methylated derivatives upon the CNS},
  author={A. Meister Ernst},
  • A. M. Ernst
  • Published 21 May 1965
  • Psychology, Medicine
  • Psychopharmacologia
SummaryThe syndrome of gnaw-compulsion was studied in rats providing evidence for a structure-effect relationship between the alcaloid apomorphine and the normal metabolite in the brain, dopamine.The following tentative conclusions could be drawn from the available data:1.The phenylethylamine-configuration with an OH-group at the para-position or at both the para- and meta-positions of the phenolring is essential for provoking a gnaw-compulsion syndrome;2.Replacement of the OH-group at the para… 
Mode of action of apomorphine and dexamphetamine on gnawing compulsion in rats
The action of apomorphine on gnaw compulsion is, just as that of dopamine, directly on effect receptors, and may act as a substitute for dopamine deficiency in Parkinson's disease.
Catalepsy induced by α-methyl-p-tyrosine and d-amphetamine: The rÔle of catecholamine metabolism
The effect of inhibition of monoamine oxidase (MAO), catechol-O-methyltransferase (COMT) and Dopa-decarboxylase on the catalepsy induced by d-amphetamine in α-methyl-p-tyrosine (α-MpT) treated rats
Impairment of responses to novelty by apomorphine and its antagonism by neuroleptics in mice
The effects of several doses of apomorphine on novelty preference (NP) in male Swiss mice were studied and it was found that AP induced a dose-dependent reduction of NP as well as of locomotor activity.
Effects of tetrahydropapaveroline and salsolinol on cerebral monoamine metabolism and their interactions with psychopharmacological drugs
THP was not found to induce any in vivo alterations in monoamineoxidase (MAO) or catechol-O-methyl transferase (COMT) activities in rat brain, and salsolinol was found to cause hypothermia while THP caused hyperthermia in the rat.
Cerebral dopamine, apomorphine and oral activity in the neonatal pig.
A lack of effect on catecholamine concentrations in any of the six brain regions examined suggested that the environmental manipulation caused no changes in the development of catechlamine-containing nerve endings.
An analysis of methylphenidate induced gnawing in guinea pigs
In the guinea pig, phenylethyl configuration with OH groups at para and meta positions of the phenyl ring does not seem to be an essential criterion for inducing Gnawing as suggested for the rat (Ernst, 1965).
Macromerine, normacromerine and bisnormacromerine: Non-psychoactive methylated derivatives of norepinephrine
These compounds are not or less psychoactive than known hallucinogenic substances and remain rather unchanged in the brain during the first hour of the conditioned avoidance response in rats after IP injection.
Metatyrosine-induced reversal of the suppression of the conditioned avoidance response in reserpine-treated rats.
  • J. Engel
  • Medicine, Chemistry
    Acta pharmacologica et toxicologica
  • 1971
The results provide further support for the hypothesis that dopamine is important for elementary motor functions whilst additional noradrenaline receptor stimulation is essential for more complex and integrated hebaviour (e.g. a conditioned avoidance response).
Regulation of Monoamine Synthesis and Utilization by Receptors
Regulation of the turnover of monoamines in the central nervous system via monoamine receptors was first suggested by the finding that neuroleptic drugs increase the brain concentrations of dopamine
Untersuchungen über die Stereotypien nach Amphetamin und Apomorphin sowie deren pharmakologische Beeinflussung
The behaviour of mice after various doses of amphetamine or apomorphine which induce stereotypies is described in details. The induced stereotyped behaviour in mice appears more differentiated than


Relation between the structure of certain methoxyphenylethylaminederivatives and the occurrence of a Hypokinetic Rigid Syndrome
  • A. M. Ernst
  • Psychology, Medicine
  • 2004
SummaryThe experiments with 9 phenylethylamine-derivatives on cats confirm that the occupation of the para-position in the phenol-ring by an OCH3-group is essential to produce a Hypokinetic Rigid
Phenomena of the Hypokinetic Rigid Type caused by O-methylation of Dopamine in the Para-position
Investigations of Carlsson suggest that the function of dopamine is not merely that of a precursor of norepinephrine, but also that it could be counteracted by dopa, the precursor of dopamine.
Distribution of noradrenaline and dopamine (3-hydroxytyramine) in the human brain and their behavior in diseases of the extrapyramidal system.
The distribution of noradrenaline und dopamine (3-hydroxytyramine) in human adult and newborn brains has been investigated. The greatest amounts of noradrenaline were found in the hypothalamus, the
Role of L-DOPA decarboxylase in the biosynthesis of catecholamines in nervous tissue and the adrenal medulla.
  • P. Holtz
  • Biology, Medicine
    Pharmacological reviews
  • 1959
The role played by L-dopa decarboxylase in the biosynthesis of catecholamines depends on the organ in which the primary product of its action, i.e., dopamine, is formed. In the suprarenal medulla
Some experiments were presented that provide indirect evidence that dopamine instead of noradrenaline is involved in the action of psychomotor stimulant drugs.
On the distribution in brain of monoamines and of enzymes responsible for their formation
Hemmungsversuche and Aktivitätsuntersuchungen der Fermente in verschiedenen Gehirnteilenin vitro sprechen dafür, dass 5-Hydroxytryptophan and 3,4-Dihydroxyphenylalanin von einem and demselben Ferment decarboxyliert werden.
Cerebral and other Diseases with Disturbance of Amine Metabolism
In seeking models to help illuminate the problem of amine metabolism in the basal ganglia, pertinent information about changed relationships between substrates and enzymes, and between granule-located and cytoplasmic constituents in “natural” disease states may be obtained from studies of accessory amine-producing tissues.
Beiträge zur Pharmakologie des Bulbocapnins
  • F. Brücke
  • Naunyn-Schmiedebergs Archiv für experimentelle Pathologie und Pharmakologie
  • 2005
Seit der tleindarstellung des im Lerehensporn (Corydalis earn) enthaltenen Haupt,alkaloids ,,Bulboeapnin", der Konsfitutionsaufklgrung dutch G a d a m e r 1 und der erst,en Besehreibung seiner
Die Katechinamine im Zentralnervensystem
Das Forschungsgebiet fiber die chemischen ~bertrggersubstanzen des Nervensystems wurde hauptsiehlieh mit tier biologischen AnMyse der ans den Endignngen tier zentrifugalen Nervenfaser wie etwa der
Beiträge zur Pharmakologie des Gehirns
  • C. Amsler
  • Chemistry
    Archiv für experimentelle Pathologie und Pharmakologie
  • 2005