Relation between shunt, aeration, and perfusion in experimental acute lung injury.

@article{Musch2008RelationBS,
  title={Relation between shunt, aeration, and perfusion in experimental acute lung injury.},
  author={Guido Musch and Giacomo Bellani and Marcos Francisco Vidal Melo and Robert Scott Harris and Tilo Winkler and T. Schr{\"o}der and Jose Gabriel Venegas},
  journal={American journal of respiratory and critical care medicine},
  year={2008},
  volume={177 3},
  pages={
          292-300
        }
}
RATIONALE In a pulmonary process characterized by spatially heterogeneous loss of aeration, the impairment of gas exchange is expected to depend on the regional distribution of perfusion relative to that of aeration. OBJECTIVES To investigate how regional aeration, shunt, and perfusion are interrelated at different levels of end-expiratory pressure and how their interplay relates to global shunt fraction in acute lung injury. METHODS Regional shunt and perfusion were assessed by imaging… CONTINUE READING

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