Relation between morphine pharmacokinetics and analgesia

Abstract

The relationship between the multicompartmental behavior of morphine and the kinetics of the analgesic effect has been investigated using a digital computer compartment analysis program. The results obtained indicate that the concentrations of morphine in the brain are not related to the analgesic effect in a “direct” manner but rather in an “indirect” way… (More)
DOI: 10.1007/BF01066062

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