Relation between localization and function of rat liver Kupffer cells.

  title={Relation between localization and function of rat liver Kupffer cells.},
  author={E. C. Sleyster and Dick L. Knook},
  journal={Laboratory investigation; a journal of technical methods and pathology},
  volume={47 5},
Kupffer cells were found to be distributed over zone 1 (periportal), zone 2 (midzonal), and zone 3 (perivenous) of the rat liver acinus in a ratio of 4:3:2. After pronase digestion of the liver, two purified tractions of Kupffer cells could be obtained by centrifugal elutriation. Liver zone marking with methylene blue prior to cell isolation revealed that one fraction contained Kupffer cells from the periportal area; the other consisted mainly of such cells from the midzonal and perivenous… CONTINUE READING
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