Relation between decreased anandamide hydrolase concentrations in human lymphocytes and miscarriage

@article{Maccarrone2000RelationBD,
  title={Relation between decreased anandamide hydrolase concentrations in human lymphocytes and miscarriage},
  author={Mauro Maccarrone and Herbert Valensise and Monica Bari and Natalia Lazzarin and Carlo Romanini and Alessandro Finazzi-Agro’},
  journal={The Lancet},
  year={2000},
  volume={355},
  pages={1326-1329}
}
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238 Citations
Highly Influential Citations
10
Background Citations
90
Methods Citations
10
Results Citations
9

238 Citations

Decreased circulating anandamide levels in preeclampsia
TLDR
It is demonstrated for the first time in the literature that serum anandamide concentrations are decreased in women with preeclampsia, and the cause and consequence of this observation remain to be determined.
Fluctuation in anandamide levels from ovulation to early pregnancy in in-vitro fertilization-embryo transfer women, and its hormonal regulation.
TLDR
It is suggested that in successful pregnancy, a higher plasma AEA level at ovulation and a significantly lower level during implantation are required, and the drop in AEA levels could be used as a biomarker for the appropriate timing of embryo transfer.
Characterization of the endocannabinoid system in early human pregnancy.
TLDR
It is shown that FAAH is expressed throughout the human first trimester placenta, in extravillous trophoblast columns, villous cytotrophoblasts, syncytiotrophoblast, and macrophages, and FAAH mRNA levels appear to be regulated during gestation, with levels peaking at 11 wk before declining again.
Anandamide hydrolase: a guardian angel of human reproduction?
Plasma levels of the endocannabinoid anandamide in women--a potential role in pregnancy maintenance and labor?
TLDR
It is suggested that successful pregnancy implantation and progression requires low levels of endocannabinoid anandamide, and at term, AEA levels dramatically increase during labor and are affected by the duration of labor, suggesting a role for AEA in normal labor.
Decreased expression of fatty acid amide hydrolase in women with polycystic ovary syndrome
TLDR
The results demonstrate that the endocannabinoid system may play an important role in menstruation, and dysregulation of the system may result in PCOS.
Differential expression of endocannabinoid system in normal and preeclamptic placentas: effects on nitric oxide synthesis.
The effect of mifepristone (RU486) on the endocannabinoid system in human plasma and first-trimester trophoblast of women undergoing termination of pregnancy.
TLDR
The effect of RU486, a P4 antagonist used to initiate medical termination of pregnancy (MTOP), on plasma AEA concentrations and the endocannabinoid system (ECS) in trophoblasts was examined and Trophoblast after MTOP demonstrated high AEA concentration with increased expression of NAPE-PLD, FAAH, and CB1.
Expression of the endocannabinoid system in human first trimester placenta and its role in trophoblast proliferation.
TLDR
Insight is provided into how elevated plasma anandamide levels increase the risk of first trimester miscarriage by demonstrating a similar pattern of expression at the protein level, with cellular localization for all three proteins concentrated within the syncytiotrophoblast layer.
Elevated anandamide and related N-acylethanolamine levels occur in the peripheral blood of women with ectopic pregnancy and are mirrored by changes in peripheral fatty acid amide hydrolase activity.
TLDR
Elevated endocannabinoid levels and reduced FAAH activity are associated with ectopic pregnancy and may modulate tubal function, suggesting dysfunctional endoc cannabinoidoid action in ectopic implantation.
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References

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TLDR
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TLDR
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