Relation between decreased anandamide hydrolase concentrations in human lymphocytes and miscarriage

M. Maccarrone; H. Valensise; M. Bari; N. Lazzarin; A. Finazzi-Agró

DOI:10.1016/S0140-6736(00)02115-2

Corpus ID: 39733100

Relation between decreased anandamide hydrolase concentrations in human lymphocytes and miscarriage

@article{Maccarrone2000RelationBD,
  title={Relation between decreased anandamide hydrolase concentrations in human lymphocytes and miscarriage},
  author={M. Maccarrone and H. Valensise and M. Bari and N. Lazzarin and A. Finazzi-Agr{\'o}},
  journal={The Lancet},
  year={2000},
  volume={355},
  pages={1326-1329}
}

M. Maccarrone, H. Valensise, +2 authors A. Finazzi-Agró

Published 2000

Medicine

The Lancet

BACKGROUND Endocannabinoids such as anandamide are thought to have adverse effects on pregnancy and embryonic development. The activity of the degradative enzyme anandamide hydrolase may therefore be crucial for prevention of excessive concentrations of anandamide in the uterus, and thus prevention of pregnancy failure or female infertility. We tested this hypothesis in a preliminary study, and then used the results to find out whether anandamide hydrolase activity could predict miscarriage in… CONTINUE READING

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