Relation between decreased anandamide hydrolase concentrations in human lymphocytes and miscarriage

@article{Maccarrone2000RelationBD,
  title={Relation between decreased anandamide hydrolase concentrations in human lymphocytes and miscarriage},
  author={Mauro Maccarrone and Herbert Valensise and Monica Bari and Natalia Lazzarin and Carlo Romanini and Alessandro Finazzi-Agro’},
  journal={The Lancet},
  year={2000},
  volume={355},
  pages={1326-1329}
}
Decreased circulating anandamide levels in preeclampsia
TLDR
It is demonstrated for the first time in the literature that serum anandamide concentrations are decreased in women with preeclampsia, and the cause and consequence of this observation remain to be determined.
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TLDR
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TLDR
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Plasma levels of the endocannabinoid anandamide in women--a potential role in pregnancy maintenance and labor?
TLDR
It is suggested that successful pregnancy implantation and progression requires low levels of endocannabinoid anandamide, and at term, AEA levels dramatically increase during labor and are affected by the duration of labor, suggesting a role for AEA in normal labor.
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TLDR
The results demonstrate that the endocannabinoid system may play an important role in menstruation, and dysregulation of the system may result in PCOS.
The effect of mifepristone (RU486) on the endocannabinoid system in human plasma and first-trimester trophoblast of women undergoing termination of pregnancy.
TLDR
The effect of RU486, a P4 antagonist used to initiate medical termination of pregnancy (MTOP), on plasma AEA concentrations and the endocannabinoid system (ECS) in trophoblasts was examined and Trophoblast after MTOP demonstrated high AEA concentration with increased expression of NAPE-PLD, FAAH, and CB1.
Expression of the endocannabinoid system in human first trimester placenta and its role in trophoblast proliferation.
TLDR
Insight is provided into how elevated plasma anandamide levels increase the risk of first trimester miscarriage by demonstrating a similar pattern of expression at the protein level, with cellular localization for all three proteins concentrated within the syncytiotrophoblast layer.
Elevated anandamide and related N-acylethanolamine levels occur in the peripheral blood of women with ectopic pregnancy and are mirrored by changes in peripheral fatty acid amide hydrolase activity.
TLDR
Elevated endocannabinoid levels and reduced FAAH activity are associated with ectopic pregnancy and may modulate tubal function, suggesting dysfunctional endoc cannabinoidoid action in ectopic implantation.
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Evidence is provided that FAAH is expressed in the mouse uterus and embryo during early pregnancy to modulate local levels of anandamide that could be important for embryo development and implantation.
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TLDR
It is shown that LIF production is associated with type 2 T-helper cells, is upregulated by IL-4 and progesterone and is downregulated byIFN-γ and IFN-α, and a decreased production of LIF, IL- 4 and IL-10 by decidual T cells of women with unexplained recurrent abortions is shown.
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