Relation between decreased anandamide hydrolase concentrations in human lymphocytes and miscarriage

@article{Maccarrone2000RelationBD,
  title={Relation between decreased anandamide hydrolase concentrations in human lymphocytes and miscarriage},
  author={Mauro Maccarrone and Herbert Valensise and Monica Bari and Natalia Lazzarin and Carlo Romanini and Alessandro Finazzi-Agro’},
  journal={The Lancet},
  year={2000},
  volume={355},
  pages={1326-1329}
}
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238 Citations
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10
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88
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238 Citations

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Decreased circulating anandamide levels in preeclampsia
TLDR
It is demonstrated for the first time in the literature that serum anandamide concentrations are decreased in women with preeclampsia, and the cause and consequence of this observation remain to be determined.
Fluctuation in anandamide levels from ovulation to early pregnancy in in-vitro fertilization-embryo transfer women, and its hormonal regulation.
TLDR
It is suggested that in successful pregnancy, a higher plasma AEA level at ovulation and a significantly lower level during implantation are required, and the drop in AEA levels could be used as a biomarker for the appropriate timing of embryo transfer.
Characterization of the endocannabinoid system in early human pregnancy.
TLDR
It is shown that FAAH is expressed throughout the human first trimester placenta, in extravillous trophoblast columns, villous cytotrophoblasts, syncytiotrophoblast, and macrophages, and FAAH mRNA levels appear to be regulated during gestation, with levels peaking at 11 wk before declining again.
Low fatty acid amide hydrolase and high anandamide levels are associated with failure to achieve an ongoing pregnancy after IVF and embryo transfer.
TLDR
It is indicated that low FAAH activity and subsequent increased AEA levels in blood might be one of the causes of implantation failure or pregnancy loss, thereby leading to a better understanding of the pathophysiological and therapeutic implications of endocannabinoids in human fertility.
Modulation of the endocannabinoid system in viable and non-viable first trimester pregnancies by pregnancy-related hormones
TLDR
The association of higher AEA levels with early pregnancy failure and with beta-hCG and PAPP-A, but not with progesterone concentrations suggest that plasma AEA Levels and pregnancy failure are linked via a mechanism that may involve trophoblastic beta- hCG, and P APP-A; but not, progestersone production.
Lipidomic approach towards deciphering anandamide effects in rat decidual cell
TLDR
In this study, the PL profile of rat decidual cells was characterized by a Mass spectrometry (MS) based lipidomic approach and a possible correlation between changes in PL of rats' membrane and AEA‐induced apoptosis was analyzed.
Anandamide hydrolase: a guardian angel of human reproduction?
Plasma levels of the endocannabinoid anandamide in women--a potential role in pregnancy maintenance and labor?
TLDR
It is suggested that successful pregnancy implantation and progression requires low levels of endocannabinoid anandamide, and at term, AEA levels dramatically increase during labor and are affected by the duration of labor, suggesting a role for AEA in normal labor.
Endocannabinoids, hormone-cytokine networks and human fertility.
TLDR
Low FAAH and consistently high blood levels of AEA, but not CB receptors or AMT, can be early (<8 weeks of gestation) markers of spontaneous abortion, potentially useful as diagnostic tools for large-scale, routine monitoring of gestation in humans.
Fluctuations of fatty acid amide hydrolase and anandamide levels during the human ovulatory cycle
TLDR
It is indicated that high fatty acid amide hydrolase activity and lowanandamide levels may be among the factors that co-operate in the success of implantation, which would add to the understanding of the pathophysiological and therapeutic implications of the endocannabinoid system in human fertility.
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