[Relation between chemical structure and antimycobacterial activity against atypical strains. XIII. Thiosalicylanilides].

Abstract

On the basis of a preliminary study of antimycobacterial activity of thiobenzanilides a series of eight thiosalicylanilides have been prepared. Synthetized compounds have been examined in vitro against Mycobacterium tuberculosis, Mycobacterium kansasii, Mycobacterium avium and Mycobacterium fortuitum. All compounds have been found very active. The values of minimal inhibitory concentrations are summarized in Table 1. 3',4'-Salicylanilide was selected for the following research. The compound have been found inactive in vivo (on experimental murine tuberculosis).

Cite this paper

@article{Waisser1998RelationBC, title={[Relation between chemical structure and antimycobacterial activity against atypical strains. XIII. Thiosalicylanilides].}, author={Karel Waisser and Lydie Kubicov{\'a} and J. E. Gregor and Jana Budov{\'a} and A Andrlov{\'a} and Jaroslav Dr{\vs}ata and Z Odlerov{\'a}}, journal={Ceská a Slovenská farmacie : casopis Ceské farmaceutické spolecnosti a Slovenské farmaceutické spolecnosti}, year={1998}, volume={47 2}, pages={84-6} }