Relation between bone mineralization, Ca absorption, and plasma Ca in phosphonate-treated rats.

@article{Trechsel1977RelationBB,
  title={Relation between bone mineralization, Ca absorption, and plasma Ca in phosphonate-treated rats.},
  author={Ulrich Trechsel and R. Schenk and J. P. Bonjour and R. Graham G. Russell and Herbert Fleisch},
  journal={The American journal of physiology},
  year={1977},
  volume={232 3},
  pages={
          E298-305
        }
}
Disodium ethane-1-hydroxy-1,1-diphosphonate (EHDP) is known to inhibit the crystallization of calcium phosphate salts in vitro. Large doses of EHDP administered in vivo inhibit skeletal mineralization, decrease intestinal calcium absorption, and produce hypercalcemia. In the present study, EHDP or one of 13 other phosphonates were given to rats at 10 mg P/kg-day sc for 7 days in order to better define the nature of the relationship between bone mineralization, intestinal absorption, and plasma… 
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