Relation between actual heart rate and autonomic effects of beta blockade in healthy men.

@article{Melenovsk2005RelationBA,
  title={Relation between actual heart rate and autonomic effects of beta blockade in healthy men.},
  author={Vojtěch Melenovsk{\'y} and J. Simek and Michal Sperl and J. P. Malik and Dan Wichterle},
  journal={The American journal of cardiology},
  year={2005},
  volume={95 8},
  pages={999-1002}
}
This study evaluated the effect of beta blockade on cardiac autonomic control and its dependence on heart rate change. The relations between RR interval duration, heart rate variability (HRV), and baroreflex sensitivity (BRS) were studied in 111 healthy men and in 21 male volunteers before and after a 100-mg oral dose of metoprolol. HRV and BRS correlated significantly with mean RR (r = 0.39, r = 0.57). Metoprolol administration increased both mean RR (from 996 to 1,176 ms, p <0.001), BRS from… CONTINUE READING

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