Relation between activated smooth-muscle cells in coronary-artery lesions and restenosis after atherectomy.

@article{Simons1993RelationBA,
  title={Relation between activated smooth-muscle cells in coronary-artery lesions and restenosis after atherectomy.},
  author={M. Simons and G. Leclerc and R. Safian and J. Isner and L. Weir and D. Baim},
  journal={The New England journal of medicine},
  year={1993},
  volume={328 9},
  pages={
          608-13
        }
}
BACKGROUND Neointimal proliferation leading to restenosis frequently develops after coronary angioplasty. This process is associated with a change in vascular smooth-muscle cells from a contractile (quiescent) phenotype to a synthetic or proliferating (activated) one. We investigated whether the presence of activated smooth-muscle cells in coronary lesions at the time of coronary atherectomy predisposes patients to subsequent restenosis. METHODS We used in situ hybridization to study the… Expand
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References

SHOWING 1-10 OF 25 REFERENCES
Evidence Implicating Nonmuscle Myosin in Restenosis: Use of In Situ Hybridization to Analyze Human Vascular Lesions Obtained by Directional Atherectomy
TLDR
These findings demonstrate that human vascular tissue obtained by percutaneous directional atherectomy constitutes appropriate biopsy material for gene expression studies at the mRNA level, and nonmuscle MHC-B mRNA is present in greater abundance among restenotic versus primary vascular stenoses. Expand
Intimal proliferation of smooth muscle cells as an explanation for recurrent coronary artery stenosis after percutaneous transluminal coronary angioplasty.
TLDR
The previously dilated coronary segment from the patient who died 62 days after angioplasty was stenosed by an extensive recent proliferation of smooth muscle cells that were distributed over the entire circumference of the intimal surface as well as within gaps in the old atherosclerotic plaques. Expand
Phenotypic features of smooth muscle cells during the evolution of experimental carotid artery intimal thickening. Biochemical and morphologic studies.
TLDR
Two adjacent luminal SMC are interconnected by gap junctions and develop focal tight junctions, supporting the view that presence of modified SMC on the luminal surface of chronically denuded vessels is not responsible for the cessation of endothelial regrowth. Expand
Common mechanisms of proliferation of smooth muscle in atherosclerosis and hypertension.
TLDR
It is intriguing to consider the possibility that this commitment process could require the release of cells from the intrinsic inhibitory effects of heparan sulfate located around the cells or the synthesis of growth factors secreted by the smooth muscle cells themselves. Expand
Cell proliferation in human coronary arteries.
TLDR
The findings imply that smooth muscle replication in advanced plaques is indolent and raise the possibility of a role for proliferating leukocytes. Expand
Differential histopathology of primary atherosclerotic and restenotic lesions in coronary arteries and saphenous vein bypass grafts: analysis of tissue obtained from 73 patients by directional atherectomy.
TLDR
Analysis of vascular tissue obtained using a directional percutaneous atherectomy device indicates that the histopathologic characteristics of the neointimal layer of restenotic lesions differ from those of the intimallayer of primary atherosclerotic lesions. Expand
Coronary atherectomy. Clinical, angiographic, and histological findings and observations regarding potential mechanisms.
TLDR
Atherectomy can predictably treat selected coronary lesions with overall safety comparable to that of conventional balloon angioplasty, although the procedure as currently performed does not derive all of its benefit from tissue removal and does not appear to prevent restenosis. Expand
Myosin isoform expression and smooth muscle cell heterogeneity in normal and atherosclerotic rabbit aorta.
TLDR
Results indicate that in experimental atherosclerosis, the accumulation in the plaque of SMC with an "immature" pattern of myosin isoform expression is accompanied by similar modifications in the differentiation pattern ofSMC of the underlying media. Expand
Long-term results of directional coronary atherectomy: predictors of restenosis.
TLDR
Six-month angiographic follow-up of patients who underwent directional coronary atherectomy during the 1st 3 years of the experience shows an overall restenosis rate of 32%, with lower rates in patients with a post-procedure lumen diameter > or = 3 mm, cholesterol level < or = 200 mg/dl or a recent myocardial infarction. Expand
Generalized model of restenosis after conventional balloon angioplasty, stenting and directional atherectomy.
TLDR
The quantitative model originally developed for restenosis after stenting or atherectomy may be generalized to include conventional balloon angioplasty and shows that the apparent differences in restenotic among the three interventions studied are due solely to differences in the immediate result provided and not to Differences in the behavior of subsequent late loss. Expand
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1
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3
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