Relation between 9-aminocamptothecin systemic exposure and tumor response in human solid tumor xenografts.

@article{Kirstein2001RelationB9,
  title={Relation between 9-aminocamptothecin systemic exposure and tumor response in human solid tumor xenografts.},
  author={Mark N. Kirstein and Peter James Houghton and Pamela J. Cheshire and L. Bruce Richmond and Angela K. Smith and Suzan K. Hanna and Clinton F Stewart},
  journal={Clinical cancer research : an official journal of the American Association for Cancer Research},
  year={2001},
  volume={7 2},
  pages={358-66}
}
9-Aminocamptothecin (9-AC) is a topoisomerase I inhibitor with activity against xenografts from childhood solid tumors; however, clinical trials with this compound have been disappointing, resulting in discontinuation of further development. The objectives of this study were to evaluate the antitumor activity of 9-AC in a panel of pediatric solid tumor xenografts and to relate the 9-AC lactone systemic exposure, defined as area under the concentration time curve (AUC), to the antitumor dose… CONTINUE READING