Relating molecular flexibility to function: a case study of tubulin.

@article{Keskin2002RelatingMF,
  title={Relating molecular flexibility to function: a case study of tubulin.},
  author={Ozlem Keskin and Stewart R Durell and Ivet Bahar and Robert L. Jernigan and David G. Covell},
  journal={Biophysical journal},
  year={2002},
  volume={83 2},
  pages={
          663-80
        }
}
Microtubules (MT), along with a variety of associated motor proteins, are involved in a range of cellular functions including vesicle movement, chromosome segregation, and cell motility. MTs are assemblies of heterodimeric proteins, alpha beta-tubulins, the structure of which has been determined by electron crystallography of zinc-induced, pacilitaxel-stabilized tubulin sheets. These data provide a basis for examining relationships between structural features and protein function. Here, we… CONTINUE READING
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