Relating influenza virus membrane fusion kinetics to stoichiometry of neutralizing antibodies at the single-particle level.

@article{Otterstrom2014RelatingIV,
  title={Relating influenza virus membrane fusion kinetics to stoichiometry of neutralizing antibodies at the single-particle level.},
  author={Jason J Otterstrom and Boerries Brandenburg and Martin H. Koldijk and Jarek Juraszek and Chan Tang and Samaneh Mashaghi and Ted H. J. Kwaks and Jaap Goudsmit and Ronald Vogels and Robert H. E. Friesen and Antoine M van Oijen},
  journal={Proceedings of the National Academy of Sciences of the United States of America},
  year={2014},
  volume={111 48},
  pages={E5143-8}
}
The ability of antibodies binding the influenza hemagglutinin (HA) protein to neutralize viral infectivity is of key importance in the design of next-generation vaccines and for prophylactic and therapeutic use. The two antibodies CR6261 and CR8020 have recently been shown to efficiently neutralize influenza A infection by binding to and inhibiting the influenza A HA protein that is responsible for membrane fusion in the early steps of viral infection. Here, we use single-particle fluorescence… CONTINUE READING
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