Relating conformation to function in integrin α5β1.

@article{Su2016RelatingCT,
  title={Relating conformation to function in integrin α5β1.},
  author={Yang Su and Wei Xia and Jing Li and Thomas Walz and Martin J Humphries and Dietmar Vestweber and Carlos Caba{\~n}as and Chafen Lu and Timothy A Springer},
  journal={Proceedings of the National Academy of Sciences of the United States of America},
  year={2016},
  volume={113 27},
  pages={
          E3872-81
        }
}
Whether β1 integrin ectodomains visit conformational states similarly to β2 and β3 integrins has not been characterized. Furthermore, despite a wealth of activating and inhibitory antibodies to β1 integrins, the conformational states that these antibodies stabilize, and the relation of these conformations to function, remain incompletely characterized. Using negative-stain electron microscopy, we show that the integrin α5β1 ectodomain adopts extended-closed and extended-open conformations as… CONTINUE READING
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