Relatedness among Basques, Portuguese, Spaniards, and Algerians studied by HLA allelic frequencies and haplotypes

@article{ArnaizVillena1997RelatednessAB,
  title={Relatedness among Basques, Portuguese, Spaniards, and Algerians studied by HLA allelic frequencies and haplotypes},
  author={Antonio Arnaiz-Villena and J Martinez-Laso and Eduardo Gomez-Casado and Nieves D{\'i}az-Campos and Paulo Santos and António Martinho and H. Breda-Coimbra},
  journal={Immunogenetics},
  year={1997},
  volume={47},
  pages={37-43}
}
Abstract HLA-A, -B, -DRB1, -DQA1, and DQB1 alleles were studied in Iberian and Algerian populations by serology and DNA sequence methodologies. [...] Key Result The results of the present HLA study in Portuguese populations show that they have features in common with Basques and Spaniards from Madrid: a high frequency of the HLA-haplotypes A29-B44-DR7 (ancient western Europeans), A2-B7-DR15 (ancient Europeans and paleo-North Africans), and A1-B8-DR3 (Europeans) are found as common characteristics.Expand
HLA genes in Macedonians and the sub-Saharan origin of the Greeks.
TLDR
Genetic distances are closer between Greeks and Ethiopian/ sub-Saharan groups than to any other Mediterranean group and Greeks cluster with Ethiopians/sub-Saharans in both neighbour joining dendrograms and correspondence analyses.
HLA Genes in the Chuvashian Population from European Russia: Admixture of Central European and Mediterranean Populations
TLDR
Present-day Chuvash who speak an Altaic-Turkic language are probably more closely related to ancient Mesopotamian-Hittites and northern European populations than to central Asia-Altaic people.
HLA-DQA1 polymorphism in autochthonous Basques from Navarre (Spain): genetic position within European and Mediterranean scopes.
TLDR
The analysis of genetic relationships among populations showed a high genetic affinity between the Basque subpopulations of Northern Navarre and Guipúzcoa, which in turn tended to plot separately from the remaining European and Mediterranean populations.
HLA in the Azores Archipelago: possible presence of Mongoloid genes.
TLDR
The results indicate that the Azorean population most likely contains an admixture of high-frequency Caucasoid, Mongoloid and, to a lesser degree, Negroid HLA genes.
HLA-DRB1 and DQB1 polymorphisms in southern France and genetic relationships with other Mediterranean populations.
TLDR
Allele frequencies are comparable to those found in other western European populations and indicate neighboring exchanges and the haplotype frequencies showed relationships with North Africans and Jewish populations, as well as the common origin of Moroccan and Lebanese Jews.
HLA Genes in Populations of the Aleutian Islands
TLDR
Results are concordant with those obtained by Y-chromosome analysis, suggesting that most male Aleut ancestors came mainly from Europe, and Aleuts are closer genetically to Europeans, including Scandinavians and English.
HLA genes in Portugal inferred from sequence-based typing: in the crossroad between Europe and Africa.
TLDR
It is found that Centre Portugal is the distribution limit of some alleles and haplotypes that characterize the North or the South of the country, despite North, Centre and South Portugal not being significantly different in allele frequencies.
Genetic relationships among Berbers and South Spaniards based on CD4 microsatellite/Alu haplotypes
TLDR
A geographical gradient of Sub-Saharan gene contribution has been detected in North Africa and the analysis of the CD4 STR/Alu haplotype variation failed to indicate any particular relationship between South Spaniards and North Africans.
The origin of Cretan populations as determined by characterization of HLA alleles.
TLDR
The results indicate that the Indoeuropean Greeks may be considered as a Mediterranean population of a more recent origin (after 2000 B.C.), while all other studied Mediterraneans (including Cretans) belong to an older substratum which was present in the area since pre-Neolithic times.
Distribution of HLA alleles in Portugal and Cabo Verde. Relationships with the slave trade route.
TLDR
The population of Madeira shows the highest genetic diversity and the presence of alleles and haplotypes usually linked to sub-Saharan populations, the haplotypes accounting for 3.5% of the total, thus revealing the admixture of European settlers with Sub-Saharan slaves.
...
1
2
3
4
5
...

References

SHOWING 1-10 OF 32 REFERENCES
HLA allele and haplotype frequencies in Algerians: Relatedness to Spaniards and Basques
TLDR
Serology and DNA typing results support the evidence that the Algerian population, mainly its paleo-North African component (Berbers), has a common descent with Basques and Spaniards, probably reflecting a preneolithic relationship between Iberians and palea-North Africans.
HLA allele and haplotype frequencies in Algerians. Relatedness to Spaniards and Basques.
TLDR
Serology and DNA typing data support the evidence that the Algerian population, mainly its paleo-North African component (Berbers), has a common descent with Basques and Spaniards, probably reflecting a preneolithic relationship between Iberians and palea-North Africans.
The contribution of the HLA-A, -B, -C and -DR, -DQ DNA typing to the study of the origins of Spaniards and Basques.
TLDR
HLA genetic distances and their respective dendrogram together with the results on complete HLA haplotypes place Basques and Spaniards closer to paleo-North African populations than to other Europeans, going in favour of the Basques being a relative genetic isolate coming from the primitive Iberian/paleo- North African people.
Evolutionary relationships of HLA-DR8 alleles and description of a new subtype (DRB1*0806) in the Algerian population.
A new HLA-DR8 allele (HLA-DRB1*0806) found in the Algerian population is described here. This allele has an exon-2 nucleotide sequence identical to that of the HLA-DRB1*0801 allele, except for a GGT
Distribution of HLA class II alleles and haplotypes in insulin-dependent Moroccan diabetics.
TLDR
The data on Moroccan diabetics, together with data on European and Northern Mediterranean patients, suggest a gradient of various HLA class II predisposing and protective markers that link these populations.
The Blood Groups of the Basques
TLDR
The facts so far cited tend to show that the Basques are a relict population which at least in Spain has suffered no significant admixture of elements akin to the general western European population.
Nomenclature for factors of the HLA system.
TLDR
A Nomenclature Committee composed of geneticists and immunologists, including specialists in tissue typing, has met after each of the Histocompatibility Workshops beginning with the Third Workshop in 1967 and met after the Sixth Workshop in Aarhus in July 1975.
Human Polymorphic Genes: World Distribution
This extensive compilation of statistical data on human gene frequencies includes entries for blood groups, proteins, enzymes, HLA systems, immunoglobins, and restriction-site polymorphisms, as well
Nomenclature for Factors of the HLA System, 1991
The W H O Nomenclature Committee for factors of the HLA system met in Hakone after the 1 l th International Histocompatibility Workshop and Conference during November 1991 to consider additions and
The neighbor-joining method: a new method for reconstructing phylogenetic trees.
TLDR
The neighbor-joining method and Sattath and Tversky's method are shown to be generally better than the other methods for reconstructing phylogenetic trees from evolutionary distance data.
...
1
2
3
4
...