Related Leucine-based Cytoplasmic Targeting Signals in Invariant Chain and Major Histocompatibility Complex Class II Molecules Control Endocytic Presentation of Distinct Determinants in a Single Protein

@article{Zhong1997RelatedLC,
  title={Related Leucine-based Cytoplasmic Targeting Signals in Invariant Chain and Major Histocompatibility Complex Class II Molecules Control Endocytic Presentation of Distinct Determinants in a Single Protein},
  author={Guangming Zhong and Paola Romagnoli and Ronald N. Germain},
  journal={The Journal of Experimental Medicine},
  year={1997},
  volume={185},
  pages={429 - 438}
}
Leucine-based signals in the cytoplasmic tail of invariant chain (Ii) control targeting of newly synthesized major histocompatibility complex class II molecules to the endocytic pathway for acquisition of antigenic peptides. Some protein determinants, however, do not require Ii for effective class II presentation, although endocytic processing is still necessary. Here we demonstrate that a dileucine-based signal in the cytoplasmic tail of the class II beta chain is critical for this Ii… CONTINUE READING
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MHC class I presentation of peptides derived from soluble exogenous antigen by a subset of cells engaged in phagocytosis

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