Related Developments in Fetal and Neonatal Endocrinology

  title={Related Developments in Fetal and Neonatal Endocrinology},
  author={L. Longo},
As noted above, the second half of the twentieth century saw a virtual explosion of research in fetal and neonatal physiology. In the UK, to a great extent this was a result of the work of the Dawes group at the Nuffield Institute, and also to investigators at Cambridge University. In Australia, this was a consequence of development of the focal groups in Melbourne, Adelaide and Sydney, and in Canada, developments at London and Toronto in Ontario. Without question, Dawes and the Nuffield… Expand


Pulsatile Endocrine Secretion in the Ovine Fetus
Publisher Summary The ontogenesis of neuroendocrine function and the physiological role of the hypothalamic-pituitary axis in the fetus are critical issues for understanding growth and development ofExpand
The pituitary gland
The first volume in Clinical Surveys in Endocrinology, The Pituitary Gland, has been written with one purpose in mind: to integrate the current knowledge in this dynamic field with the existing body of information already available to the clinician. Expand
Endocrine functions of the human fetus and placenta
The various hormonal parameters used or advocated for the assessment of fetal well-being are critically evaluated and the possible factors involved in the regulatory mechanisms are reviewed. Expand
Endocrine and paracrine regulation of birth at term and preterm.
In human pregnancy, it is argued that high circulating progesterone concentrations are required to effect regionalization of uterine activity, with predominantly relaxation in the lower uterine segment, allowing contractions in the fundal region to precipitate delivery. Expand
Effects of electrocoagulation of the foetal lamb hypophysis on growth and development.
It is concluded that the hypophysis of the foetal lamb subserves many of the functions attributed to it during extrauterine life. Expand
Endocrine control of parturition.
This chapter aims to bring together some of the abovementioned theories to show that, for example, the role of the fetus in the initiation of parturition and the concept of progesterone withdrawal may be part of the same mechanism. Expand
The formation of estrogens by central neuroendocrine tissues.
Much of what I will discuss here today relates to brain differentiation in rodents. This subject was the interest of two outstanding British scientists, Geoffrey Harris and Peter MacDonald. HarrisExpand
Failure of initiation of parturition after electrocoagulation of the pituitary of the fetal lamb.
It is concluded that the integrity of the fetal pituitary and probably of the hypothalamus is essential to the initiation of parturition in the sheep. Expand
Adrenal maturation of the sheep fetus during late pregnancy.
There was a close correlation between the levels of fetal plasma corticosteroids and the number of ACTH receptors during late pregnancy, and it has been suggested that receptor modulation is one of the factors responsible for the enhanced sensitivity of the fetal adrenals to ACTH just before parturition. Expand
Intrauterine Transfusion of Foetus in Haemolytic Disease
In the management of the pregnancy complicated by rhesus sensitization the guidance given by amniotic-fluid pigmentation has greatly reduced the perinatal mortality from haemolytic disease. Expand