Relapsing and remitting multiple sclerosis: Pathology of the newly forming lesion

@article{Barnett2004RelapsingAR,
  title={Relapsing and remitting multiple sclerosis: Pathology of the newly forming lesion},
  author={Michael Harry Barnett and John W. Prineas},
  journal={Annals of Neurology},
  year={2004},
  volume={55}
}
The study describes the clinical and pathological findings in 12 patients with relapsing and remitting multiple sclerosis, who died during or shortly after the onset of a relapse. Pathological changes not previously associated with the formation of new symptomatic lesions were observed in seven cases, namely, extensive oligodendrocyte apoptosis and microglial activation in myelinated tissue containing few or no lymphocytes or myelin phagocytes. No current laboratory model of multiple sclerosis… 
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