Relapses contribute significantly to the risk of Plasmodium vivax infection and disease in Papua New Guinean children 1-5 years of age.

@article{Betuela2012RelapsesCS,
  title={Relapses contribute significantly to the risk of Plasmodium vivax infection and disease in Papua New Guinean children 1-5 years of age.},
  author={Inoni Betuela and Anna Rosanas-Urgell and Benson Kiniboro and Danielle I. Stanisic and Lornah Samol and Elisa de Lazzari and Hernando A Del Portillo and Peter Siba and Pedro Luis Chas Alonso and Quique Bassat and Ivo Mueller},
  journal={The Journal of infectious diseases},
  year={2012},
  volume={206 11},
  pages={1771-80}
}
BACKGROUND Plasmodium vivax forms long-lasting hypnozoites in the liver. How much they contribute to the burden of P. vivax malaria in children living in highly endemic areas is unknown. METHODS In this study, 433 Papua New Guinean children aged 1-5 years were Randomized to receive artesunate (7 days) plus primaquine (14 days), artesunate alone or no treatment and followed up actively for recurrent Plasmodium infections and disease for 40 weeks. RESULTS Treatment with artesunate-primaquine… CONTINUE READING

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