RelB is the NF-kappaB subunit downstream of NIK responsible for osteoclast differentiation.

@article{Vaira2008RelBIT,
  title={RelB is the NF-kappaB subunit downstream of NIK responsible for osteoclast differentiation.},
  author={Sergio Vaira and Trevor Johnson and Angela C Hirbe and Muhammad A Alhawagri and Imani Anwisye and B{\'e}n{\'e}dicte Sammut and Julie O'Neal and Wei Zou and Katherine N. Weilbaecher and Roberta Faccio and Deborah V Novack},
  journal={Proceedings of the National Academy of Sciences of the United States of America},
  year={2008},
  volume={105 10},
  pages={3897-902}
}
NF-kappaB inducing kinase (NIK) is required for osteoclastogenesis in response to pathologic stimuli, and its loss leads to functional blockade of both alternative and classical NF-kappaB caused by cytoplasmic retention by p100. We now show that deletion of p100 restores the capacity of NIK-deficient osteoclast (OC) precursors to differentiate and normalizes RelB and p65 signaling. Differentiation of NIK-/- precursors is also restored by overexpression of RelB, but not p65. Additionally, RelB… CONTINUE READING

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