RelB enhances prostate cancer growth: implications for the role of the nuclear factor-kappaB alternative pathway in tumorigenicity.

@article{Xu2009RelBEP,
  title={RelB enhances prostate cancer growth: implications for the role of the nuclear factor-kappaB alternative pathway in tumorigenicity.},
  author={Yong Xu and Sajni Josson and Fang Fang and Terry D. Oberley and Daret K. St. Clair and X. Steven Wan and Yulan Sun and Vasudevan Bakthavatchalu and Anantharaman Muthuswamy and William H. St. Clair},
  journal={Cancer research},
  year={2009},
  volume={69 8},
  pages={3267-71}
}
The nuclear factor-kappaB (NF-kappaB) classic pathway is thought to be critical for tumorigenesis, but little is known about the role of the NF-kappaB alternative pathway in cancer development. Recently, high constitutive nuclear levels of RelB have been observed in human prostate cancer specimens with high Gleason scores. Here, we used four complementary approaches to test whether RelB contributes to tumorigenicity of prostate cancer. Inhibiting RelB in aggressive androgen-independent PC-3… CONTINUE READING