RelB NF-kappaB represses estrogen receptor alpha expression via induction of the zinc finger protein Blimp1.

@article{Wang2009RelBNR,
  title={RelB NF-kappaB represses estrogen receptor alpha expression via induction of the zinc finger protein Blimp1.},
  author={Xiaobo Wang and Karine Belguise and Christine F. O'Neill and Nuria S{\'a}nchez-Morgan and Mathilde Romagnoli and Sean F. Eddy and Nora D. Mineva and Ziyang Yu and Chengyin Min and Vickery E Trinkaus-Randall and Dany Chalbos and Gail E. Sonenshein},
  journal={Molecular and cellular biology},
  year={2009},
  volume={29 14},
  pages={3832-44}
}
Aberrant constitutive expression of NF-kappaB subunits, reported in more than 90% of breast cancers and multiple other malignancies, plays pivotal roles in tumorigenesis. Higher RelB subunit expression was demonstrated in estrogen receptor alpha (ERalpha)-negative breast cancers versus ERalpha-positive ones, due in part to repression of RelB synthesis by ERalpha signaling. Notably, RelB promoted a more invasive phenotype in ERalpha-negative cancers via induction of the BCL2 gene. We report here… CONTINUE READING
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