RelB/p50 dimers are differentially regulated by tumor necrosis factor-alpha and lymphotoxin-beta receptor activation: critical roles for p100.

@article{Derudder2003RelBp50DA,
  title={RelB/p50 dimers are differentially regulated by tumor necrosis factor-alpha and lymphotoxin-beta receptor activation: critical roles for p100.},
  author={Emmanuel Derudder and Emmanuel Dejardin and Linda Louise Pritchard and Douglas R Green and Marie Korner and V{\'e}ronique Baud},
  journal={The Journal of biological chemistry},
  year={2003},
  volume={278 26},
  pages={23278-84}
}
Tumor necrosis factor-alpha (TNF-alpha) and lymphotoxin-beta receptor (LTbetaR) signaling both play important roles in inflammatory and immune responses through activation of NF-kappaB. Using various deficient mouse embryonic fibroblast cells, we have compared the signaling pathways leading to NF-kappaB induction in response to TNF-alpha and LTbetaR activation. We demonstrate that LTbetaR ligation induces not only RelA/p50 dimers but also RelB/p50 dimers, whereas TNF-alpha induces only RelA/p50… CONTINUE READING

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