RelA control of IkappaBalpha phosphorylation: a positive feedback loop for high affinity NF-kappaB complexes.

@article{Yang2003RelACO,
  title={RelA control of IkappaBalpha phosphorylation: a positive feedback loop for high affinity NF-kappaB complexes.},
  author={Lin Yang and Kehinde Ross and Eva E. Qwarnstrom},
  journal={The Journal of biological chemistry},
  year={2003},
  volume={278 33},
  pages={30881-8}
}
NF-kappaB-IkappaB complex formation regulates the level and specificity of NF-kappaB activity. Quantitative analyses showed that RelA-NF-kappaB-induced IkappaBalpha binding is regulated through inhibitor retention and phosphorylation. RelA caused an increase in IkappaBalpha phosphorylation and in degradation, which was enhanced monotonically with inhibitor… CONTINUE READING