RelA-Associated Inhibitor Blocks Transcription of Human Immunodeficiency Virus Type 1 by Inhibiting NF-κB and Sp1 Actions

@article{Takada2002RelAAssociatedIB,
  title={RelA-Associated Inhibitor Blocks Transcription of Human Immunodeficiency Virus Type 1 by Inhibiting NF-$\kappa$B and Sp1 Actions},
  author={Norio Takada and Takaomi Sanda and Hiroshi Okamoto and Jian-ping Yang and Kaori Asamitsu and L Sarol and Genjiro Kimura and Hiroaki Uranishi and Toshifumi Tetsuka and Takashi Okamoto},
  journal={Journal of Virology},
  year={2002},
  volume={76},
  pages={8019 - 8030}
}
ABSTRACT RelA-associated inhibitor (RAI) is an inhibitor of nuclear factor κB (NF-κB) newly identified by yeast two-hybrid screen as an interacting protein of the p65 (RelA) subunit. In this study, we attempted to examine the effect of RAI on transcription and replication of human immunodeficiency virus type 1 (HIV-1). We found that RAI inhibited gene expression from the HIV-1 long terminal repeat (LTR) even at the basal level. Upon in vitro DNA-binding reactions, RAI could directly block the… 
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The isolated RING finger motif-containing protein, AO7, previously identified as an interacting protein with a ubiquitin-conjugating enzyme, Ubc5B, was found to interacts with the p65 TAD and modulates its transcriptional activity.
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TLDR
The results clearly show that HspBP1 acts as an endogenous negative regulator of HIV-1 gene-expression and replication by suppressing NF-κB-mediated activation of viral transcription.
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AKIP1 Enhances NF-κB-dependent Gene Expression by Promoting the Nuclear Retention and Phosphorylation of p65*
TLDR
Findings indicate a positive role of AKIP1 in NF-κB signaling and suggest a novel mechanism by whichAKIP1 augments the transcriptional competence of NF-σκB.
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