Rel/NF-kappaB double mutants reveal that cellular immunity is central to Drosophila host defense.

@article{Matova2006RelNFkappaBDM,
  title={Rel/NF-kappaB double mutants reveal that cellular immunity is central to Drosophila host defense.},
  author={Nina Matova and Kathryn V Anderson},
  journal={Proceedings of the National Academy of Sciences of the United States of America},
  year={2006},
  volume={103 44},
  pages={16424-9}
}
Studies on Drosophila immunity have focused on the humoral response, whereas less is known about the Drosophila cellular immunity. Here we show that mutants that lack the Drosophila Rel/NF-kappaB proteins Dorsal and Dif have very few blood cells, are constitutively infected by opportunistic microbes, and die from infection as larvae. When the double mutants are grown in microbe-free conditions, the animals are rescued from chronic infection and many survive to adult stages. Thus, Dif and Dorsal… CONTINUE READING