Rel/NF-kappa B/I kappa B signal transduction in the generation and treatment of human cancer.

@article{Gilmore2002RelNFkappaBK,
  title={Rel/NF-kappa B/I kappa B signal transduction in the generation and treatment of human cancer.},
  author={Thomas D. Gilmore and Maria-Emily R Gapuzan and Demetrios Kalaitzidis and Daniel T. Starczynowski},
  journal={Cancer letters},
  year={2002},
  volume={181 1},
  pages={
          1-9
        }
}
The Rel/NF-kappa B family is a group of structurally-related, tightly-regulated transcription factors that control the expression of a multitude of genes involved in key cellular and organismal processes. The Rel/NF-kappa B signal transduction pathway is misregulated in a variety of human cancers, especially ones of lymphoid cell origin, due either to genetic changes (such as chromosomal rearrangements, amplifications, and mutations) or to chronic activation of the pathway by epigenetic… CONTINUE READING
Highly Cited
This paper has 22 citations. REVIEW CITATIONS

From This Paper

Topics from this paper.

Citations

Publications citing this paper.
Showing 1-10 of 14 extracted citations

Exploring a novel NF-ĸB- inhibiting nanoparticle for periodontitis therapy

Kameswara Satya, Srikanth Upadhyayula, Satya Upadhyayula, Soma Upadhyayula, Shanti Pittampalli
2018
View 8 Excerpts
Method Support
Highly Influenced