Rejuvenation of the aging thymus: growth hormone-mediated and ghrelin-mediated signaling pathways.

@article{Taub2010RejuvenationOT,
  title={Rejuvenation of the aging thymus: growth hormone-mediated and ghrelin-mediated signaling pathways.},
  author={Dennis D. Taub and William J. Murphy and Dan L. Longo},
  journal={Current opinion in pharmacology},
  year={2010},
  volume={10 4},
  pages={408-24}
}
One of the major fundamental causes for the aging of the immune system is the structural and functional involution of the thymus, and the associated decline in de novo naïve T-lymphocyte output. This loss of naïve T-cell production weakens the ability of the adaptive immune system to respond to new antigenic stimuli and eventually leads to a peripheral T-cell bias to the memory phenotype. While the precise mechanisms responsible for age-associated thymic involution remain unknown, a variety of… CONTINUE READING

From This Paper

Topics from this paper.
35 Citations
0 References
Similar Papers

Citations

Publications citing this paper.
Showing 1-10 of 35 extracted citations

Similar Papers

Loading similar papers…