Rejuvenation of human cardiac progenitor cells with Pim-1 kinase.

@article{Mohsin2013RejuvenationOH,
  title={Rejuvenation of human cardiac progenitor cells with Pim-1 kinase.},
  author={Sadia Mohsin and Mohsin U. Khan and Jonathan Nguyen and Monique Alkatib and Sailay Siddiqi and Nirmala Hariharan and Kathleen Wallach and M. Monsanto and Natalie A. Gude and Walter P. Dembitsky and Mark A Sussman},
  journal={Circulation research},
  year={2013},
  volume={113 10},
  pages={
          1169-79
        }
}
RATIONALE Myocardial function is enhanced by adoptive transfer of human cardiac progenitor cells (hCPCs) into a pathologically challenged heart. However, advanced age, comorbidities, and myocardial injury in patients with heart failure constrain the proliferation, survival, and regenerative capacity of hCPCs. Rejuvenation of senescent hCPCs will improve the outcome of regenerative therapy for a substantial patient population possessing functionally impaired stem cells. OBJECTIVE Reverse… CONTINUE READING

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