Rejuvenating senolytics

@article{Baumann2018RejuvenatingS,
  title={Rejuvenating senolytics},
  author={Kim Baumann},
  journal={Nature Reviews Molecular Cell Biology},
  year={2018},
  volume={19},
  pages={543}
}
  • K. Baumann
  • Published 27 July 2018
  • Medicine
  • Nature Reviews Molecular Cell Biology
Eliminating senescent cells by administering senolytic drugs can improve healthspan and lifespan in mice. 
5 Citations
Inflammation, epigenetics, and metabolism converge to cell senescence and ageing: the regulation and intervention
TLDR
This review focuses on the present findings and emerging concepts in epigenetic, inflammatory, and metabolic regulations and the consequences of the ageing process. Expand
The ageing epigenome and its rejuvenation
TLDR
The epigenetic changes that occur during ageing and the rapidly increasing knowledge of how these epigenetic mechanisms have an effect on healthspan and lifespan extension are discussed, and questions to guide future research on interventions to rejuvenate the epigenome and delay ageing processes are outlined. Expand
Developmental programming of adult haematopoiesis system
TLDR
Evidence, reporting and discussing related theories, and results of studies described in the literature are provided, and how it is possible to intervene to correct foetal mal-programming is suggested. Expand
The plasticity of ageing and the rediscovery of ground-state prevention
  • A. Blasimme
  • Medicine
  • History and philosophy of the life sciences
  • 2021
TLDR
This paper focuses on how, in contrast to most classical accounts of ageing, biomedicine today construes the ageing process as a modifiable trajectory, and suggests that such an explanatory framework about ageing creates the epistemological conditions for the rise of a peculiar form of prevention that does not aim to address a specific condition. Expand
Reflections on a century of vitamin E research: Looking at the past with an eye on the future.
  • A. Azzi
  • Medicine
  • Free radical biology & medicine
  • 2021
The name vitamin E, was given by Barnett and Sure who suggested that the factor proposed by Evans and Bishop as substance "X," be termed vitamin "E" as the next vitamin after the A, B, C and DExpand

References

Senolytics Improve Physical Function and Increase Lifespan in Old Age
TLDR
It is demonstrated that transplanting relatively small numbers of senescent cells into young mice is sufficient to cause persistent physical dysfunction, as well as to spread cellular senescence to host tissues, and a senolytic can reverse this dysfunction and potently increase lifespan in aged mice. Expand