Rejection of the transplanted uterus is suppressed by cyclosporine A in a semi-allogeneic mouse model.

@article{Wranning2007RejectionOT,
  title={Rejection of the transplanted uterus is suppressed by cyclosporine A in a semi-allogeneic mouse model.},
  author={Caiza Alm{\'e}n Wranning and Randa Racho El-Akouri and Klaus Groth and Johan M{\"o}lne and Adalberto Parra and Mats Br{\"a}nnstr{\"o}m},
  journal={Human reproduction},
  year={2007},
  volume={22 2},
  pages={372-9}
}
BACKGROUND A mouse uterus transplantation model has previously been developed for studies of various aspects of uterine transplantation, which in the future may be used as treatment for uterine infertility. The aim of the study was to evaluate the effect of the immunosuppressant cyclosporine A (CyA) on the rejection of the allotransplanted uterus in the mouse. METHODS C57BL/6 mice were recipients of uteri from F1 hybrids (C57BL/6 x CBA/ca). Transplanted mice received vehicle (control, n=5… CONTINUE READING

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