Rejection of parental meth-a tumor on concomitant inoculation of meth-a cells infected retrovirally with the interferon-gamma gene into (balb/cxc57bl/6)f-1 mice.

@article{Harutsumi1995RejectionOP,
  title={Rejection of parental meth-a tumor on concomitant inoculation of meth-a cells infected retrovirally with the interferon-gamma gene into (balb/cxc57bl/6)f-1 mice.},
  author={M Harutsumi and Toshiki Aji and Akira Manki and Masaki Hikida and Hiroko Omori and Yasuhiro Watanabe and Yasufumi Teramura and Kagemasa Kuribayashi and Yoshiki Seino and Eiichi Nakayama},
  journal={International journal of oncology},
  year={1995},
  volume={7 2},
  pages={233-8}
}
The IFN-gamma gene was introduced retrovirally into Meth A cells. IFN-gamma gene infected Meth A (K gamma) cells were highly antigenic and regressed in CB6F(1) mice. Concomitant immunization of CB6F(1), mice with IFN-gamma gene infected Meth A (K gamma) cells after inoculation of parental Meth A protected the mice from parental tumor growth. 1x10(6) infectant Meth A (K gamma) cells protected the mice from growth of 1x10(6) parental Meth A cells, but 2x10(6) infectant cells did not, suggesting… CONTINUE READING