Rejection of disseminated metastases of colon carcinoma by synergism of IL-12 gene therapy and 4-1BB costimulation.

@article{Chen2000RejectionOD,
  title={Rejection of disseminated metastases of colon carcinoma by synergism of IL-12 gene therapy and 4-1BB costimulation.},
  author={Shimin Chen and Khiem B Pham-Nguyen and Olivier Martinet and Y Huang and Winnie Yang and Swan N. Thung and L K Chen and Robert S. Mittler and Savio L. C. Woo},
  journal={Molecular therapy : the journal of the American Society of Gene Therapy},
  year={2000},
  volume={2 1},
  pages={39-46}
}
In an orthotopic model of metastatic colon carcinoma established in the liver of mice, we have previously shown that the natural killer (NK) cells were the major effectors after intratumoral delivery of a recombinant adenovirus expressing the murine IL-12 gene. However, tumor cure and long-term survival were achieved only in a minority of animals. In the present study, we generated an effective antitumoral CD8(+ ) T-cell response by the combination of IL-12 gene therapy and systemic delivery of… CONTINUE READING

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