Reirradiation alternating with docetaxel and cisplatin in inoperable recurrence of head-and-neck cancer: a prospective phase I/II trial.

@article{Hehr2005ReirradiationAW,
  title={Reirradiation alternating with docetaxel and cisplatin in inoperable recurrence of head-and-neck cancer: a prospective phase I/II trial.},
  author={Thomas Hehr and Johannes Classen and Claus Belka and Stefan Welz and Juergen W Schaefer and Assen Koitschev and Michael Bamberg and Wilfried Budach},
  journal={International journal of radiation oncology, biology, physics},
  year={2005},
  volume={61 5},
  pages={1423-31}
}
PURPOSE Inoperable locoregional recurrences of head-and-neck cancer in a previously irradiated volume represent a therapeutic dilemma. Chemotherapy alone has no curative potential, whereas reirradiation and concurrent chemoradiation can salvage a small fraction of patients. Mucosal toxicity of concurrent chemoradiation requires substantial dose reduction of chemotherapy. Alternating chemoradiation offers the chance to give both full-dose chemotherapy and radiotherapy. The latter may provide a… CONTINUE READING

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