Reintroduction of a characterized Mit tRNA glycine mutation into yeast mitochondria provides a new tool for the study of human neurodegenerative diseases.

Abstract

We report the identification and characterization of a new mutation (ts9) in the Saccharomyces cerevisiae mitochondrial genome, which was first genetically mapped in the tRNAgly region and further identified by means of sequencing as consisting of a G to A transition at position 30 in the tRNA. The mutation causes an almost complete disappearance of mature… (More)

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@article{Rohou2001ReintroductionOA, title={Reintroduction of a characterized Mit tRNA glycine mutation into yeast mitochondria provides a new tool for the study of human neurodegenerative diseases.}, author={H. Rohou and Stefano De Francisci and Tatiana A Rinaldi and Laura Frontali and Monique Bolotin-Fukuhara}, journal={Yeast}, year={2001}, volume={18 3}, pages={219-27} }