Reintroduction of CEBPA in MN1-overexpressing hematopoietic cells prevents their hyperproliferation and restores myeloid differentiation.

@article{Kandilci2009ReintroductionOC,
  title={Reintroduction of CEBPA in MN1-overexpressing hematopoietic cells prevents their hyperproliferation and restores myeloid differentiation.},
  author={Ayten Kandilci and Gerard C. Grosveld},
  journal={Blood},
  year={2009},
  volume={114 8},
  pages={1596-606}
}
Forced expression of MN1 in primitive mouse hematopoietic cells causes acute myeloid leukemia and impairs all-trans retinoic acid-induced granulocytic differentiation. Here, we studied the effects of MN1 on myeloid differentiation and proliferation using primary human CD34(+) hematopoietic cells, lineage-depleted mouse bone marrow cells, and bipotential (granulocytic/monocytic) human acute myeloid leukemia cell lines. We show that exogenous MN1 stimulated the growth of CD34(+) cells, which was… CONTINUE READING

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Cebpa Is Critical for the Mn1-induced Phenotype

DE Zhang, CJ Hetherington, S Meyers
BLOOD, • 2009

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