Reinstatement of heroin self-administration habits: morphine prompts and naltrexone discourages renewed responding after extinction

@article{Stewart1992ReinstatementOH,
  title={Reinstatement of heroin self-administration habits: morphine prompts and naltrexone discourages renewed responding after extinction},
  author={Jane Stewart and Roy Wise},
  journal={Psychopharmacology},
  year={1992},
  volume={108},
  pages={79-84}
}
The effects of morphine, naltrexone, and nalorphine were studied in rats trained to lever-press for intravenous heroin and then tested under conditions of non-reinforcement. Animals were reinforced for lever-pressing on a continuous reinforcement schedule (100 µg/kg per infusion) for 2–3 h each day following which reinforcement was terminated and animals were studied under extinction conditions for the remainder of the session. Each day following the termination of responding under extinction… CONTINUE READING

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