Reinstalling antitumor immunity by inhibiting tumor-derived immunosuppressive molecule IDO through RNA interference.

@article{Zheng2006ReinstallingAI,
  title={Reinstalling antitumor immunity by inhibiting tumor-derived immunosuppressive molecule IDO through RNA interference.},
  author={Xiufen Zheng and James D. Koropatnick and Mu J Li and Xusheng Zhang and Fengjun Ling and Xiubao Ren and Xishan Hao and Hongtao Sun and Costin Vladau and Jacob A. Franek and Biao Feng and Bradley L. Urquhart and Robert Zhong and David J. Freeman and B. Bueno Garc{\'i}a and Weiping Min},
  journal={Journal of immunology},
  year={2006},
  volume={177 8},
  pages={5639-46}
}
Tumor-derived immune suppression is a major impediment to successful immune/gene cancer therapy. In the present study, we describe a novel strategy to disrupt tumor-derived immune suppression by silencing a tolerogenic molecule of tumor origin, IDO, using small interfering RNA (siRNA). Silencing of IDO in B16F10 cells in vitro using IDO-siRNA prevented catabolism of tryptophan and inhibited apoptosis of T cells. IDO-siRNA treatment of B16F10 cells in vitro inhibited subsequent growth, tumor… CONTINUE READING

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