Reinforcing properties of ethanol in neonatal rats: involvement of the opioid system.

@article{Nizhnikov2006ReinforcingPO,
  title={Reinforcing properties of ethanol in neonatal rats: involvement of the opioid system.},
  author={Michael Eduard Nizhnikov and Elena I. Varlinskaya and Evgeniy S Petrov and Norman E. Spear},
  journal={Behavioral neuroscience},
  year={2006},
  volume={120 2},
  pages={267-80}
}
Toward understanding why infant rats ingest high levels of ethanol without initiation procedures, the authors tested effects of mu and kappa receptor antagonists on ethanol reinforcement in neonatal rats. After an intracisternal injection of CTOP (micro antagonist), nor-Binaltorphimine (kappa antagonist), or saline, newborn (3-hr-old) rats were given conditioning pairings of an odor with intraorally infused ethanol or a surrogate nipple with ethanol administered intraperitoneally (to minimize… CONTINUE READING

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