Reinforcing effects of caffeine, ephedrine, and their binary combination in rats.

@article{Briscoe1998ReinforcingEO,
  title={Reinforcing effects of caffeine, ephedrine, and their binary combination in rats.},
  author={Richard J. Briscoe and Stanislav Vaně{\vc}ek and M Vallett and Thomas John Baird and Frank A. Holloway and D V Gauvin},
  journal={Pharmacology, biochemistry, and behavior},
  year={1998},
  volume={60 3},
  pages={685-93}
}
The reinforcing effects of caffeine, ephedrine, and caffeine + ephedrine combinations were tested in rats maintained to self-administer 0.5 mg/kg/injection of cocaine in daily 4 h limited access periods. The dose-response relationship for cocaine demonstrated a a typical inverted U-shaped function. The dose-dependent administration of cocaine was stable over the 3-day substitution epochs. Similar to earlier reports, neither caffeine nor ephedrine engendered stable patterns of self-injections… CONTINUE READING